Hydroxylation mediates chromatin demethylation
نویسندگان
چکیده
منابع مشابه
Demethylation, Methylation and 3'-Hydroxylation of Isoflavones bv Fusarium Fungi
Isoflavones, Fusarium, Methylation, Demethylation, 3'-Hydroxylation, Metabolism Several introductionary reactions of isoflavone metabolism by Fusarium fungi are reported. Fu sarium avenaceum hydroxylates formononetin in the 3'-position yielding 3',7-dihydroxy-4'-methoxyisoflavone (calycosin). 3'-Hydroxylation of biochanin A to 3/,5,7-trihydroxy-4/-methoxyisoflavone (pratensein) has been observ...
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DNA methylation inhibitors such as 5-aza-2'-deoxycytidine (5-Aza-CdR) are currently used for the treatment of myelodysplastic syndrome. Although global DNA demethylation has been observed after treatment, it is unclear to what extent demethylation induces changes in nucleosome occupancy, a key determinant of gene expression. We use the colorectal cancer cell line HCT116 as a model to address th...
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The metabolism of nortriptyline was studied in vitro using cDNA-expressed human cytochrome P450 isozymes 1A2, 3A4, 2C19, and 2D6, CYP2D6 was the sole isozyme mediating hydroxylation of nortriptyline, the quantitatively most important metabolic pathway, and only (E)-10-OH-nortriptyline was formed. CYP2D6, 2C19, and 1A2, mentioned in decreasing order of significance, mediated the demethylation re...
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The primary metabolic pathways of caffeine are 3-N-demethylation to paraxanthine (CYP1A2), 1-N-demethylation to theobromine and 7-N-demethylation to theophylline (CYP1A2 and other enzymes), and 8-hydroxylation to 1,3,7-trimethyluric acid (CYP3A). The aim of the present study was to investigate the influence of phenothiazine neuroleptics (chlorpromazine, levomepromazine, thioridazine, perazine) ...
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Cytochrome P450 3A4 is known to catalyze the metabolism of both endogenous substrates (such as the 6 beta-hydroxylation of testosterone) and many important therapeutic agents, including the N-demethylation of erythromycin. However, erythromycin and testosterone have been reported to have little or no effect on the metabolism of each other by recombinant CYP3A4. In an effort to understand the ba...
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ژورنال
عنوان ژورنال: Journal of Biochemistry
سال: 2012
ISSN: 0021-924X
DOI: 10.1093/jb/mvs003